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What is the role of tryptophan to the human body?
May 08, 2018

Tryptophan is an important precursor substance in auxin biosynthesis in plants. It can synthesize auxin through tryptophan. More than 95% of tryptophan in human body is decomposed by tryptophan -2, 3- oxygenase. When the liver cells are damaged, the amount of this enzyme decreases and the activity decreases. The disease caused by the metabolic process of tryptophan is seen in the decline of liver function, tryptophanuria, hydroxuria and xanthate, and the latter 3 are hereditary diseases, which are due to the major metabolic pathways from tryptophan to nicotinic acid and coenzyme I. Tryptophan in plasma is divided into 2 parts: free and albumin bound. 

About 90% of tryptophan is bound to albumin and 10% is free tryptophan. More than 95% of tryptophan in human body is catalyzed by tryptophan -2, 3- oxygenase in liver cells. When the liver cells were damaged, the enzyme content and enzyme activity decreased, the tryptophan concentration in plasma increased as the ability of tryptophan to decompose tryptophan decreased.