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The Physiological Function Of 5- Hydroxytryptophan
May 08, 2018

5-HTP can be converted into serotonin in the body, but serotonin can not enter the brain through the blood brain barrier, so it must be 5-HTP first passing through the blood brain barrier and then converting it into serotonin in the brain to truly play the role of stabilizing the mood and promoting sleep quality. After oral 5-HTP, only about 1/3 to 1/2 can be used. With the transformation of the brain into serotonin, a large part of the brain is transformed into serotonin before entering the blood circulation of the brain, and this part is a physiological effect that has no positive significance.

A number of studies have indicated that 5-HTP has certain physiological functions. According to clinical research, taking 5-HTP can significantly improve the mood of patients with depression. In addition, 5-HTP can also promote sleep quality and improve mild insomnia. There is also evidence of clinical evidence that 5-HTP has a analgesic effect that can improve the discomfort of some myalgia patients and also play a role in the improvement of chronic stressful headaches. Clinical studies have found that taking 5-HTP can reduce the frequency of recurrent headache attacks and increase the concentration of endorphins in the body. The enkephalin is the natural body of the body. The secretion of pain and pleasure substances, the increase in the concentration of enkephalin, can make the body feel happy. Animal tests also found that 5-HTP could increase the concentration of blood in leptin, increase appetite control and avoid binge eating. A clinical study for 19 obese women found that 8 mg (mg) per kilogram of weight per kilogram per day was five weeks, and the average weight fell without a diet prescription. As low as 5%, similar results also appeared in other clinical studies that were longer and for patients with non - Isle dependent diabetes, so 5-HTP could be used to assist in the appetite control of obese people. However, it is worth noting that the intensity of these evidences is still insufficient, and the physiological role of 5-HTP is still controversial.

Because the research of 5-HTP is not thorough enough, the possible side effects and drug cross action are not yet clear.  However, due to no serious adverse reactions reported at present, it can be considered that 5-HTP will not produce serious adverse reactions at a certain dose. On the other hand, diarrhea and vomiting are common adverse reactions due to the rapid formation of upper intestinal serotonin. [5-7] has reported that 5-HTP can cause eosinophilic myalgia syndrome (EMS) and is more serious, leading to extreme muscle tenderness, myalgia, and blood abnormalities. However, there is evidence that EMS is caused by 5-HTP supplement pollutants. In addition, the cross effects of the drugs currently reported are as follows:

When combined with monoamine oxidase inhibitors or SSRI antidepressants, 5-HTP can lead to acute serotonin syndrome.

When combined with Cabi do Ba (for the treatment of symptoms of Parkinson's disease), 5-HTP is prone to nausea and vomiting; however, this can be alleviated by granisetron.